Caloric restriction delays age-related methylation drift
نویسندگان
چکیده
منابع مشابه
Caloric restriction delays disease onset and mortality in rhesus monkeys.
Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at th...
متن کاملCaloric restriction delays cardiac ageing in rats: role of mitochondria.
AIMS We tested whether long-term caloric restriction (CR) corrects pre-existing manifestations of cardiac ageing in rats. METHODS AND RESULTS The age-specific effects of CR (-40%, 6 months) on mortality, left ventricular (LV) function, mitochondrial function, oxidative damage, and apoptosis were analysed in young (6 + 6 months) and senescent rats (24 + 6 months). CR in senescent rats signific...
متن کاملActivation-Induced Apoptosis in T cells: Effect of Age and Caloric Restriction
We have previously shown that the proliferative response of T cells to antigenic or mitogenic stimulus decreased with age and that caloric resection (CR) attenuated the age-related decline in proliferation and IL-2 expression. Because activation-induced apoptosis is known to regulate cell proliferation and eliminate the high number of activated cells during an immune response, it was of interes...
متن کاملAttenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise.
The cellular basis of age-related behavioral decline remains obscure but alterations in synapses are likely candidates. Accordingly, the beneficial effects on neural function of caloric restriction and exercise, which are among the most effective anti-aging treatments known, might also be mediated by synapses. As a starting point in testing these ideas, we studied the skeletal neuromuscular jun...
متن کاملCaloric restriction reduces age-related and all-cause mortality in rhesus monkeys
Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-associated disorders in short-lived species, from unicellular organisms to laboratory mice and rats. The value of CR as a tool to understand human ageing relies on translatability of CR's effects in primates. Here we show that CR significantly improves age-related and all-cause survival in monkeys on a...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/s41467-017-00607-3